node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVU_1914 | DVU_2272 | DVU_1914 | DVU_2272 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | 0.900 |
DVU_1914 | DVU_3047 | DVU_1914 | DVU_3047 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | 0.965 |
DVU_1914 | ilvC | DVU_1914 | DVU_1378 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.807 |
DVU_1914 | ilvD | DVU_1914 | DVU_3373 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.971 |
DVU_1914 | ilvE | DVU_1914 | DVU_3197 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.981 |
DVU_1914 | ldh | DVU_1914 | DVU_0600 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.835 |
DVU_1914 | leuA | DVU_1914 | DVU_2981 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.923 |
DVU_1914 | leuC | DVU_1914 | DVU_2982 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily. | 0.979 |
DVU_2272 | DVU_1914 | DVU_2272 | DVU_1914 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.900 |
DVU_2272 | DVU_3047 | DVU_2272 | DVU_3047 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | 0.801 |
DVU_2272 | ilvE | DVU_2272 | DVU_3197 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.800 |
DVU_2272 | ldh | DVU_2272 | DVU_0600 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.917 |
DVU_2272 | leuA | DVU_2272 | DVU_2981 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.901 |
DVU_2272 | leuC | DVU_2272 | DVU_2982 | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily. | 0.802 |
DVU_3047 | DVU_1914 | DVU_3047 | DVU_1914 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.965 |
DVU_3047 | DVU_2272 | DVU_3047 | DVU_2272 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | Formate acetyltransferase, putative; Identified by similarity to SP:P32674; match to protein family HMM PF01228; match to protein family HMM PF02901. | 0.801 |
DVU_3047 | hom | DVU_3047 | DVU_0890 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | Homoserine dehydrogenase; Identified by similarity to SP:P19582; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.896 |
DVU_3047 | ilvC | DVU_3047 | DVU_1378 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.505 |
DVU_3047 | ilvD | DVU_3047 | DVU_3373 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.981 |
DVU_3047 | ilvE | DVU_3047 | DVU_3197 | Aminotransferase, class IV; Identified by match to protein family HMM PF01063. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.926 |