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ilvE ilvE ilvD ilvD leuA leuA Dde_2049 Dde_2049 Dde_0255 Dde_0255 panB panB Dde_2731 Dde_2731 ilvC ilvC Dde_0398 Dde_0398 Dde_1266 Dde_1266 Dde_2168 Dde_2168
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)    
Predicted Functional Partners:
ilvD
TIGRFAM: Dihydroxy-acid dehydratase; KEGG: dvu:DVU3373 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 0.989
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.978
Dde_2049
TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; KEGG: dvm:DvMF_0275 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.975
Dde_0255
PFAM: Aminotransferase, class IV; KEGG: dvm:DvMF_2383 aminotransferase class IV.
  
  
 
0.925
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.917
Dde_2731
PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: dvm:DvMF_1412 homoserine dehydrogenase.
 
 
 0.907
ilvC
Ketol-acid reductoisomerase / Dehydropantoate reductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.775
Dde_0398
TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: dvl:Dvul_2624 acetolactate synthase catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central region.
  
 
 0.690
Dde_1266
TIGRFAM: Diaminopropionate ammonia-lyase; Diaminopropionate ammonia-lyase, subgroup; KEGG: ctc:CTC00071 diaminopropionate ammonia-lyase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
  
  
 0.690
Dde_2168
TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: dvm:DvMF_0153 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central region.
  
 
 0.690
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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