node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dde_0174 | carB | Dde_0174 | Dde_0333 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | 0.438 |
Dde_0174 | hisA | Dde_0174 | Dde_1465 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: dvl:Dvul_1955 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.413 |
Dde_0174 | hisF | Dde_0174 | Dde_0331 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.843 |
Dde_0174 | hisH | Dde_0174 | Dde_0332 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.831 |
Dde_1401 | carB | Dde_1401 | Dde_0333 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | 0.596 |
Dde_1401 | hisA | Dde_1401 | Dde_1465 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: dvl:Dvul_1955 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.890 |
Dde_1401 | hisB | Dde_1401 | Dde_1467 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | KEGG: dvl:Dvul_1953 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.927 |
Dde_1401 | hisD | Dde_1401 | Dde_1008 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.929 |
Dde_1401 | hisF | Dde_1401 | Dde_0331 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.917 |
Dde_1401 | hisG | Dde_1401 | Dde_3566 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.872 |
Dde_1401 | hisH | Dde_1401 | Dde_0332 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.925 |
Dde_1401 | hisI | Dde_1401 | Dde_3567 | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.909 |
carB | Dde_0174 | Dde_0333 | Dde_0174 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.438 |
carB | Dde_1401 | Dde_0333 | Dde_1401 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | Histidinol-phosphate transaminase; KEGG: dvl:Dvul_1935 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II. | 0.596 |
carB | hisA | Dde_0333 | Dde_1465 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: dvl:Dvul_1955 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.690 |
carB | hisB | Dde_0333 | Dde_1467 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | KEGG: dvl:Dvul_1953 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.525 |
carB | hisC | Dde_0333 | Dde_1453 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | TIGRFAM: Histidinol-phosphate aminotransferase; KEGG: dvl:Dvul_1964 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.534 |
carB | hisD | Dde_0333 | Dde_1008 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.669 |
carB | hisF | Dde_0333 | Dde_0331 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.976 |
carB | hisG | Dde_0333 | Dde_3566 | SMART: MGS-like; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dvm:DvMF_2306 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Carbamoyl phosphate synthase, large subunit, N-terminal; Belongs to the CarB family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.551 |