node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dde_0370 | Dde_1660 | Dde_0370 | Dde_1660 | Multi-sensor hybrid histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; KEGG: dvm:DvMF_2273 PAS/PAC sensor hybrid histidine kinase; SMART: Signal transduction response regulator, receiver region; PAS; PAC motif; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; ATP-binding region, ATPase-like. | KEGG: dvm:DvMF_0568 hypothetical protein. | 0.512 |
Dde_0370 | clpB | Dde_0370 | Dde_1661 | Multi-sensor hybrid histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; KEGG: dvm:DvMF_2273 PAS/PAC sensor hybrid histidine kinase; SMART: Signal transduction response regulator, receiver region; PAS; PAC motif; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; ATP-binding region, ATPase-like. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.690 |
Dde_1659 | Dde_1660 | Dde_1659 | Dde_1660 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | KEGG: dvm:DvMF_0568 hypothetical protein. | 0.932 |
Dde_1659 | clpB | Dde_1659 | Dde_1661 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.858 |
Dde_1659 | clpP | Dde_1659 | Dde_2220 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.489 |
Dde_1659 | dnaK | Dde_1659 | Dde_1023 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |
Dde_1659 | groL | Dde_1659 | Dde_2473 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.788 |
Dde_1659 | grpE | Dde_1659 | Dde_1025 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.947 |
Dde_1659 | htpG | Dde_1659 | Dde_1147 | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | ATP-binding region ATPase domain protein; Molecular chaperone. Has ATPase activity. | 0.874 |
Dde_1660 | Dde_0370 | Dde_1660 | Dde_0370 | KEGG: dvm:DvMF_0568 hypothetical protein. | Multi-sensor hybrid histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; KEGG: dvm:DvMF_2273 PAS/PAC sensor hybrid histidine kinase; SMART: Signal transduction response regulator, receiver region; PAS; PAC motif; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; ATP-binding region, ATPase-like. | 0.512 |
Dde_1660 | Dde_1659 | Dde_1660 | Dde_1659 | KEGG: dvm:DvMF_0568 hypothetical protein. | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | 0.932 |
Dde_1660 | clpB | Dde_1660 | Dde_1661 | KEGG: dvm:DvMF_0568 hypothetical protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.838 |
Dde_1660 | dnaJ | Dde_1660 | Dde_0248 | KEGG: dvm:DvMF_0568 hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.613 |
clpB | Dde_0370 | Dde_1661 | Dde_0370 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Multi-sensor hybrid histidine kinase; TIGRFAM: PAS; PFAM: ATP-binding region, ATPase-like; Signal transduction response regulator, receiver region; PAS fold; HAMP linker domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; KEGG: dvm:DvMF_2273 PAS/PAC sensor hybrid histidine kinase; SMART: Signal transduction response regulator, receiver region; PAS; PAC motif; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; ATP-binding region, ATPase-like. | 0.690 |
clpB | Dde_1659 | Dde_1661 | Dde_1659 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: dvm:DvMF_0569 chaperone DnaJ domain protein; PFAM: Chaperone DnaJ, C-terminal; Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. | 0.858 |
clpB | Dde_1660 | Dde_1661 | Dde_1660 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | KEGG: dvm:DvMF_0568 hypothetical protein. | 0.838 |
clpB | clpP | Dde_1661 | Dde_2220 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.925 |
clpB | clpS | Dde_1661 | Dde_2100 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.858 |
clpB | dnaJ | Dde_1661 | Dde_0248 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.720 |
clpB | dnaK | Dde_1661 | Dde_1023 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.967 |