node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dde_1225 | Dde_2115 | Dde_1225 | Dde_2115 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | 0.918 |
Dde_1225 | Dde_3397 | Dde_1225 | Dde_3397 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | 0.900 |
Dde_1225 | fmt | Dde_1225 | Dde_0014 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
Dde_1225 | folD | Dde_1225 | Dde_0296 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
Dde_1225 | glyA | Dde_1225 | Dde_2432 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
Dde_1225 | purN | Dde_1225 | Dde_2835 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.928 |
Dde_1225 | thyX | Dde_1225 | Dde_2321 | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.913 |
Dde_1425 | Dde_2433 | Dde_1425 | Dde_2433 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: dvl:Dvul_1855 CMP/dCMP deaminase, zinc-binding. | 0.948 |
Dde_1425 | purN | Dde_1425 | Dde_2835 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.541 |
Dde_1425 | thyX | Dde_1425 | Dde_2321 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.940 |
Dde_1425 | tmk | Dde_1425 | Dde_2338 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.956 |
Dde_2115 | Dde_1225 | Dde_2115 | Dde_1225 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | 0.918 |
Dde_2115 | Dde_3397 | Dde_2115 | Dde_3397 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Formyltetrahydrofolate dehydrogenase; KEGG: azl:AZL_a06020 methionyl-tRNA formyltransferase; PFAM: Formyl transferase, N-terminal. | 0.918 |
Dde_2115 | fmt | Dde_2115 | Dde_0014 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
Dde_2115 | folD | Dde_2115 | Dde_0296 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.650 |
Dde_2115 | glyA | Dde_2115 | Dde_2432 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.951 |
Dde_2115 | purN | Dde_2115 | Dde_2835 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.929 |
Dde_2115 | thyX | Dde_2115 | Dde_2321 | Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.915 |
Dde_2433 | Dde_1425 | Dde_2433 | Dde_1425 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: dvl:Dvul_1855 CMP/dCMP deaminase, zinc-binding. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.948 |
Dde_2433 | glyA | Dde_2433 | Dde_2432 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: dvl:Dvul_1855 CMP/dCMP deaminase, zinc-binding. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.659 |