STRINGSTRING
metE metE Dde_2115 Dde_2115 metK metK ahcY ahcY Dde_2525 Dde_2525 Dde_3007 Dde_3007 metG metG Dde_2731 Dde_2731 Dde_0276 Dde_0276 Dde_2146 Dde_2146 Dde_3080 Dde_3080
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
metE5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa)    
Predicted Functional Partners:
Dde_2115
Methionine synthase; KEGG: dvm:DvMF_0476 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding.
  
 
 0.989
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.983
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.976
Dde_2525
TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dvm:DvMF_3034 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.938
Dde_3007
PFAM: Protein of unknown function DUF39; KEGG: dvm:DvMF_1464 protein of unknown function DUF39.
     
 0.916
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.915
Dde_2731
PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: dvm:DvMF_1412 homoserine dehydrogenase.
  
 
 0.912
Dde_0276
Cystathionine beta-lyase; KEGG: dal:Dalk_4468 aminotransferase class I and II; PFAM: Aminotransferase, class I/II.
    
 0.905
Dde_2146
NIL domain-containing protein; PFAM: NIL domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: dvl:Dvul_1236 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein.
     
 0.900
Dde_3080
TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: dvm:DvMF_2658 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
 
 0.872
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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