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glyA glyA Dde_1996 Dde_1996 folD folD Dde_1691 Dde_1691 Dde_0174 Dde_0174 Dde_0377 Dde_0377 purN purN gcvH gcvH gcvPA gcvPA Dde_2525 Dde_2525 Dde_3034 Dde_3034
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)    
Predicted Functional Partners:
Dde_1996
TIGRFAM: Glycine cleavage system T protein; KEGG: dvl:Dvul_1403 glycine cleavage system T protein; PFAM: Glycine cleavage T-protein, N-terminal; Glycine cleavage T-protein, C-terminal barrel.
 
 0.997
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.988
Dde_1691
PFAM: Glycine cleavage system P-protein, N-terminal; KEGG: dvm:DvMF_0223 glycine dehydrogenase subunit 2.
  
 
 0.986
Dde_0174
PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region.
  
 0.978
Dde_0377
KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region.
  
 0.978
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.978
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.975
gcvPA
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
  
 
 0.971
Dde_2525
TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dvm:DvMF_3034 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.963
Dde_3034
KEGG: das:Daes_0636 L-serine ammonia-lyase; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain.
  
 
 0.956
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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