node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dde_0174 | Dde_0377 | Dde_0174 | Dde_0377 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | 0.997 |
Dde_0174 | Dde_1764 | Dde_0174 | Dde_1764 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | KEGG: dvm:DvMF_0434 phosphoribosylformylglycinamidine synthase. | 0.909 |
Dde_0174 | folD | Dde_0174 | Dde_0296 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
Dde_0174 | glyA | Dde_0174 | Dde_2432 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
Dde_0174 | purD | Dde_0174 | Dde_3458 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: dvl:Dvul_2453 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.947 |
Dde_0174 | purE | Dde_0174 | Dde_3459 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.940 |
Dde_0174 | purL | Dde_0174 | Dde_3191 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.886 |
Dde_0174 | purN | Dde_0174 | Dde_2835 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.998 |
Dde_0174 | purT | Dde_0174 | Dde_2767 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.971 |
Dde_0377 | Dde_0174 | Dde_0377 | Dde_0174 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.997 |
Dde_0377 | Dde_1764 | Dde_0377 | Dde_1764 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | KEGG: dvm:DvMF_0434 phosphoribosylformylglycinamidine synthase. | 0.917 |
Dde_0377 | folD | Dde_0377 | Dde_0296 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
Dde_0377 | glyA | Dde_0377 | Dde_2432 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
Dde_0377 | purD | Dde_0377 | Dde_3458 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: dvl:Dvul_2453 phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.957 |
Dde_0377 | purE | Dde_0377 | Dde_3459 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.942 |
Dde_0377 | purL | Dde_0377 | Dde_3191 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] | 0.849 |
Dde_0377 | purN | Dde_0377 | Dde_2835 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
Dde_0377 | purT | Dde_0377 | Dde_2767 | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.971 |
Dde_1764 | Dde_0174 | Dde_1764 | Dde_0174 | KEGG: dvm:DvMF_0434 phosphoribosylformylglycinamidine synthase. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dvu:DVU3206 phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region. | 0.909 |
Dde_1764 | Dde_0377 | Dde_1764 | Dde_0377 | KEGG: dvm:DvMF_0434 phosphoribosylformylglycinamidine synthase. | KEGG: dvm:DvMF_1946 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS-like; AICARFT/IMPCHase bienzyme, formylation region. | 0.917 |