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leuD leuD leuC leuC leuB leuB leuA leuA Dde_2049 Dde_2049 ilvC ilvC ilvD ilvD Dde_0171 Dde_0171 Dde_0520 Dde_0520 Dde_1032 Dde_1032 Dde_1253 Dde_1253
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query proteins and first shell of interactors
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textmining
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protein homology
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leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)    
Predicted Functional Partners:
leuC
Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 0.999
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.995
Dde_2049
TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; KEGG: dvm:DvMF_0275 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.980
ilvC
Ketol-acid reductoisomerase / Dehydropantoate reductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.958
ilvD
TIGRFAM: Dihydroxy-acid dehydratase; KEGG: dvu:DVU3373 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.954
Dde_0171
KEGG: dvl:Dvul_0177 threonine synthase; TIGRFAM: Threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
  
  
 0.865
Dde_0520
Putative cache sensor protein; PFAM: Pyruvate carboxyltransferase; Cache; KEGG: dvm:DvMF_1549 pyruvate carboxyltransferase.
 
  
 0.831
Dde_1032
TIGRFAM: Pyruvate kinase; KEGG: dvm:DvMF_0965 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family.
  
 
 0.826
Dde_1253
PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; KEGG: dsa:Desal_0725 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
  
 
 0.824
Your Current Organism:
Desulfovibrio alaskensis
NCBI taxonomy Id: 207559
Other names: D. alaskensis G20, Desulfovibrio alaskensis G20, Desulfovibrio alaskensis str. G20, Desulfovibrio alaskensis strain G20, Desulfovibrio desulfuricans subsp. desulfuricans str. G20
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