STRINGSTRING
lexA lexA AGE24938.1 AGE24938.1 recA recA AGE26242.1 AGE26242.1 dinB dinB AGE27445.1 AGE27445.1 AGE27846.1 AGE27846.1 AGE26243.1 AGE26243.1 AGE24940.1 AGE24940.1 AGE24450.1 AGE24450.1 AGE24495.1 AGE24495.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)    
Predicted Functional Partners:
AGE24938.1
Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
  
  
 0.889
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.873
AGE26242.1
Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair.
 
 
 0.598
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.598
AGE27445.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.557
AGE27846.1
DNA-directed DNA polymerase.
  
 
 0.536
AGE26243.1
Hypothetical protein; COG0468 RecA/RadA recombinase.
 
   
 0.529
AGE24940.1
COG1309 Transcriptional regulator.
     
 0.486
AGE24450.1
Hypothetical protein.
   
  
 0.467
AGE24495.1
COG3141 Uncharacterized protein conserved in bacteria.
   
  
 0.467
Your Current Organism:
Pseudomonas poae
NCBI taxonomy Id: 1282356
Other names: P. poae RE*1-1-14, Pseudomonas poae RE*1-1-14
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