node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGE25797.1 | AGE26875.1 | H045_08635 | H045_14050 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 0.955 |
AGE25797.1 | acs | H045_08635 | H045_14870 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.921 |
AGE25797.1 | glcB | H045_08635 | H045_18485 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.951 |
AGE25797.1 | prpB | H045_08635 | H045_14055 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.875 |
AGE25797.1 | sucC | H045_08635 | H045_05330 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.863 |
AGE25797.1 | sucD | H045_08635 | H045_05335 | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.854 |
AGE26875.1 | AGE25797.1 | H045_14050 | H045_08635 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | AMP-binding protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.955 |
AGE26875.1 | AGE26877.1 | H045_14050 | H045_14060 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | COG1802 Transcriptional regulators. | 0.692 |
AGE26875.1 | acnB | H045_14050 | H045_09545 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; COG1049 Aconitase B; Belongs to the aconitase/IPM isomerase family. | 0.843 |
AGE26875.1 | acnD | H045_14050 | H045_14045 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | Aconitate hydratase; COG1048 Aconitase A. | 0.996 |
AGE26875.1 | acs | H045_14050 | H045_14870 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.955 |
AGE26875.1 | glcB | H045_14050 | H045_18485 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.561 |
AGE26875.1 | prpB | H045_14050 | H045_14055 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.959 |
AGE26875.1 | prpF | H045_14050 | H045_14040 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | COG2828 Uncharacterized protein conserved in bacteria. | 0.899 |
AGE26875.1 | sucC | H045_14050 | H045_05330 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.840 |
AGE26875.1 | sucD | H045_14050 | H045_05335 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.628 |
AGE26877.1 | AGE26875.1 | H045_14060 | H045_14050 | COG1802 Transcriptional regulators. | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 0.692 |
AGE26877.1 | acnD | H045_14060 | H045_14045 | COG1802 Transcriptional regulators. | Aconitate hydratase; COG1048 Aconitase A. | 0.497 |
AGE26877.1 | prpB | H045_14060 | H045_14055 | COG1802 Transcriptional regulators. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.833 |
AGE26877.1 | prpF | H045_14060 | H045_14040 | COG1802 Transcriptional regulators. | COG2828 Uncharacterized protein conserved in bacteria. | 0.604 |