node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGE24330.1 | apt | H045_01270 | H045_13695 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.929 |
AGE24330.1 | gmk | H045_01270 | H045_20270 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.947 |
AGE24330.1 | guaA | H045_01270 | H045_16085 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.953 |
AGE24330.1 | guaB | H045_01270 | H045_16090 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.938 |
AGE24330.1 | purL | H045_01270 | H045_15985 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.523 |
AGE24330.1 | rdgB | H045_01270 | H045_19270 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.909 |
AGE24330.1 | surE | H045_01270 | H045_03300 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AGE24330.1 | xpt | H045_01270 | H045_20125 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.927 |
apt | AGE24330.1 | H045_13695 | H045_01270 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | 0.929 |
apt | gmk | H045_13695 | H045_20270 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.951 |
apt | guaA | H045_13695 | H045_16085 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.986 |
apt | purL | H045_13695 | H045_15985 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.740 |
apt | surE | H045_13695 | H045_03300 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.907 |
apt | xpt | H045_13695 | H045_20125 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.911 |
gmk | AGE24330.1 | H045_20270 | H045_01270 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | 0.947 |
gmk | apt | H045_20270 | H045_13695 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.951 |
gmk | guaA | H045_20270 | H045_16085 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.969 |
gmk | guaB | H045_20270 | H045_16090 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.434 |
gmk | lysS | H045_20270 | H045_02970 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | COG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.471 |
gmk | purL | H045_20270 | H045_15985 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.752 |