node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGE24140.1 | AGE24330.1 | H045_00320 | H045_01270 | COG0104 Adenylosuccinate synthase. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | 0.961 |
AGE24140.1 | AGE25382.1 | H045_00320 | H045_06550 | COG0104 Adenylosuccinate synthase. | Stationary-phase survival protein SurE; COG0496 Predicted acid phosphatase. | 0.924 |
AGE24140.1 | AGE28513.1 | H045_00320 | H045_22275 | COG0104 Adenylosuccinate synthase. | COG1011 Predicted hydrolase (HAD superfamily). | 0.909 |
AGE24140.1 | guaA | H045_00320 | H045_16085 | COG0104 Adenylosuccinate synthase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.919 |
AGE24140.1 | guaB | H045_00320 | H045_16090 | COG0104 Adenylosuccinate synthase. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.988 |
AGE24140.1 | purA | H045_00320 | H045_23470 | COG0104 Adenylosuccinate synthase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.934 |
AGE24140.1 | purH | H045_00320 | H045_23845 | COG0104 Adenylosuccinate synthase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.971 |
AGE24140.1 | rdgB | H045_00320 | H045_19270 | COG0104 Adenylosuccinate synthase. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.662 |
AGE24140.1 | surE | H045_00320 | H045_03300 | COG0104 Adenylosuccinate synthase. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.924 |
AGE24140.1 | xpt | H045_00320 | H045_20125 | COG0104 Adenylosuccinate synthase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.668 |
AGE24330.1 | AGE24140.1 | H045_01270 | H045_00320 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | COG0104 Adenylosuccinate synthase. | 0.961 |
AGE24330.1 | AGE25382.1 | H045_01270 | H045_06550 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Stationary-phase survival protein SurE; COG0496 Predicted acid phosphatase. | 0.900 |
AGE24330.1 | AGE28513.1 | H045_01270 | H045_22275 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | COG1011 Predicted hydrolase (HAD superfamily). | 0.900 |
AGE24330.1 | guaA | H045_01270 | H045_16085 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.953 |
AGE24330.1 | guaB | H045_01270 | H045_16090 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.938 |
AGE24330.1 | purA | H045_01270 | H045_23470 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.925 |
AGE24330.1 | purH | H045_01270 | H045_23845 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.943 |
AGE24330.1 | rdgB | H045_01270 | H045_19270 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.909 |
AGE24330.1 | surE | H045_01270 | H045_03300 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
AGE24330.1 | xpt | H045_01270 | H045_20125 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.927 |