node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGE24208.1 | AGE27611.1 | H045_00660 | H045_17745 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | COG0307 Riboflavin synthase alpha chain. | 0.944 |
AGE24208.1 | AGE28072.1 | H045_00660 | H045_20050 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | 0.910 |
AGE24208.1 | metK | H045_00660 | H045_18865 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.406 |
AGE24208.1 | ribB | H045_00660 | H045_17740 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.604 |
AGE24208.1 | ribD | H045_00660 | H045_17750 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.748 |
AGE24208.1 | ribH | H045_00660 | H045_17735 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.718 |
AGE24208.1 | ribH-2 | H045_00660 | H045_14795 | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.718 |
AGE27611.1 | AGE24208.1 | H045_17745 | H045_00660 | COG0307 Riboflavin synthase alpha chain. | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | 0.944 |
AGE27611.1 | AGE28072.1 | H045_17745 | H045_20050 | COG0307 Riboflavin synthase alpha chain. | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | 0.904 |
AGE27611.1 | nusB | H045_17745 | H045_17730 | COG0307 Riboflavin synthase alpha chain. | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.584 |
AGE27611.1 | ribA | H045_17745 | H045_17715 | COG0307 Riboflavin synthase alpha chain. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.989 |
AGE27611.1 | ribB | H045_17745 | H045_17740 | COG0307 Riboflavin synthase alpha chain. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
AGE27611.1 | ribD | H045_17745 | H045_17750 | COG0307 Riboflavin synthase alpha chain. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
AGE27611.1 | ribH | H045_17745 | H045_17735 | COG0307 Riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.997 |
AGE27611.1 | ribH-2 | H045_17745 | H045_14795 | COG0307 Riboflavin synthase alpha chain. | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.991 |
AGE27611.1 | thiL | H045_17745 | H045_17725 | COG0307 Riboflavin synthase alpha chain. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.561 |
AGE28072.1 | AGE24208.1 | H045_20050 | H045_00660 | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196 FAD synthase; Belongs to the ribF family. | 0.910 |
AGE28072.1 | AGE27611.1 | H045_20050 | H045_17745 | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | COG0307 Riboflavin synthase alpha chain. | 0.904 |
AGE28072.1 | ribD | H045_20050 | H045_17750 | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.930 |
AGE28072.1 | ribH | H045_20050 | H045_17735 | HAD-superfamily hydrolase, subfamily IA, variant 1 and 3; COG1011 Predicted hydrolase (HAD superfamily). | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.904 |