node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGE24449.1 | AGE25081.1 | H045_01865 | H045_05025 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.908 |
AGE24449.1 | AGE26444.1 | H045_01865 | H045_11895 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.931 |
AGE24449.1 | ilvD | H045_01865 | H045_19400 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.917 |
AGE24449.1 | leuA | H045_01865 | H045_16120 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.916 |
AGE25081.1 | AGE24449.1 | H045_05025 | H045_01865 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.908 |
AGE25081.1 | AGE26444.1 | H045_05025 | H045_11895 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.908 |
AGE25081.1 | ilvD | H045_05025 | H045_19400 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.911 |
AGE25081.1 | leuA | H045_05025 | H045_16120 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.906 |
AGE26444.1 | AGE24449.1 | H045_11895 | H045_01865 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.931 |
AGE26444.1 | AGE25081.1 | H045_11895 | H045_05025 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.908 |
AGE26444.1 | AGE27397.1 | H045_11895 | H045_16670 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.538 |
AGE26444.1 | ilvC | H045_11895 | H045_16660 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.610 |
AGE26444.1 | ilvD | H045_11895 | H045_19400 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.965 |
AGE26444.1 | leuA | H045_11895 | H045_16120 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.983 |
AGE26444.1 | leuC | H045_11895 | H045_12215 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.618 |
AGE26444.1 | leuD | H045_11895 | H045_12210 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.475 |
AGE26444.1 | panB | H045_11895 | H045_16770 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.922 |
AGE27397.1 | AGE26444.1 | H045_16670 | H045_11895 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.538 |
AGE27397.1 | ilvC | H045_16670 | H045_16660 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
AGE27397.1 | ilvD | H045_16670 | H045_19400 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.889 |