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hemC hemC AGE28056.1 AGE28056.1 AGE25323.1 AGE25323.1 AGE28041.1 AGE28041.1 cobA-2 cobA-2 hemE hemE hemA hemA cobA cobA hemL hemL AGE28055.1 AGE28055.1 AGE28054.1 AGE28054.1
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second shell of interactors
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textmining
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protein homology
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hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
AGE28056.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.997
AGE25323.1
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
AGE28041.1
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.993
cobA-2
uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
  
 0.983
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.982
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.979
cobA
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.974
hemL
COG0001 Glutamate-1-semialdehyde aminotransferase.
 
  
 0.894
AGE28055.1
uroporphyrin-III C-methyltransferase; COG2959 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.848
AGE28054.1
Putative HemY domain protein; COG3071 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.810
Your Current Organism:
Pseudomonas poae
NCBI taxonomy Id: 1282356
Other names: P. poae RE*1-1-14, Pseudomonas poae RE*1-1-14
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