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trpA trpA trpB trpB trpC trpC trpF trpF AGI22400.1 AGI22400.1 trpD trpD trpE trpE AGI23984.1 AGI23984.1 AGI21931.1 AGI21931.1 ilvA ilvA AGI22245.1 AGI22245.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 0.999
trpC
COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 
 0.998
trpF
COG0135 Phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
 
  
 0.986
AGI22400.1
COG0512 Anthranilate/para-aminobenzoate synthases component II.
 
  
 0.970
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.964
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.939
AGI23984.1
COG0147 Anthranilate/para-aminobenzoate synthases component I.
 
  
 0.938
AGI21931.1
Ectoine utilization protein EutB; COG1171 Threonine dehydratase.
  
 
 0.925
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.925
AGI22245.1
Cystathionine beta-synthase; COG0031 Cysteine synthase.
    
 0.922
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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