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hemC hemC AGI22135.1 AGI22135.1 AGI22154.1 AGI22154.1 hemA hemA hemE hemE AGI24007.1 AGI24007.1 cysG cysG hemL hemL AGI22136.1 AGI22136.1 AGI22137.1 AGI22137.1 AGI25709.1 AGI25709.1
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query proteins and first shell of interactors
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second shell of interactors
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textmining
co-expression
protein homology
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hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
AGI22135.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.997
AGI22154.1
COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.996
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.984
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.983
AGI24007.1
uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
  
 0.982
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.973
hemL
COG0001 Glutamate-1-semialdehyde aminotransferase.
 
  
 0.894
AGI22136.1
Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.857
AGI22137.1
HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis.
  
  
 0.813
AGI25709.1
Heme d1 biosynthesis protein NirJ; COG0535 Predicted Fe-S oxidoreductases; Belongs to the precorrin methyltransferase family.
   
 0.762
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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