node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI22135.1 | AGI22136.1 | H681_01265 | H681_01270 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.995 |
AGI22135.1 | AGI22137.1 | H681_01265 | H681_01275 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | 0.919 |
AGI22135.1 | AGI22154.1 | H681_01265 | H681_01360 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.850 |
AGI22135.1 | AGI24007.1 | H681_01265 | H681_10675 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.926 |
AGI22135.1 | cysG | H681_01265 | H681_13625 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.964 |
AGI22135.1 | hemA | H681_01265 | H681_20640 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.606 |
AGI22135.1 | hemC | H681_01265 | H681_01260 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
AGI22135.1 | hemE | H681_01265 | H681_22585 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.946 |
AGI22136.1 | AGI22135.1 | H681_01270 | H681_01265 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.995 |
AGI22136.1 | AGI22137.1 | H681_01270 | H681_01275 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | 0.980 |
AGI22136.1 | AGI24007.1 | H681_01270 | H681_10675 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.905 |
AGI22136.1 | cysG | H681_01270 | H681_13625 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.913 |
AGI22136.1 | hemC | H681_01270 | H681_01260 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.857 |
AGI22136.1 | hemE | H681_01270 | H681_22585 | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.910 |
AGI22137.1 | AGI22135.1 | H681_01275 | H681_01265 | HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.919 |
AGI22137.1 | AGI22136.1 | H681_01275 | H681_01270 | HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | Hypothetical protein; COG2959 Uncharacterized enzyme of heme biosynthesis. | 0.980 |
AGI22137.1 | hemC | H681_01275 | H681_01260 | HemY protein; COG3071 Uncharacterized enzyme of heme biosynthesis. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.813 |
AGI22154.1 | AGI22135.1 | H681_01360 | H681_01265 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.850 |
AGI22154.1 | AGI24007.1 | H681_01360 | H681_10675 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.849 |
AGI22154.1 | AGI25709.1 | H681_01360 | H681_19210 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Heme d1 biosynthesis protein NirJ; COG0535 Predicted Fe-S oxidoreductases; Belongs to the precorrin methyltransferase family. | 0.695 |