STRINGSTRING
erpA erpA AGI25653.1 AGI25653.1 iscS iscS AGI23300.1 AGI23300.1 nfuA nfuA hscB hscB AGI23212.1 AGI23212.1 AGI22388.1 AGI22388.1 argC argC sucA sucA AGI25373.1 AGI25373.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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erpAIron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. (116 aa)    
Predicted Functional Partners:
AGI25653.1
Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
  
 0.805
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.705
AGI23300.1
COG0278 Glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily.
 
 0.651
nfuA
Hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.644
hscB
Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
  
 
 0.615
AGI23212.1
Folate-binding protein YgfZ; COG0354 Predicted aminomethyltransferase related to GcvT; Belongs to the GcvT family.
 
 
 0.613
AGI22388.1
Heat shock protein DnaJ-like protein; COG1076 DnaJ-domain-containing proteins 1.
  
 
 0.554
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
       0.548
sucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes.
  
   
 0.491
AGI25373.1
COG4775 Outer membrane protein/protective antigen OMA87.
  
 
 0.487
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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