STRINGSTRING
birA birA AGI26111.1 AGI26111.1 AGI22422.1 AGI22422.1 bioB bioB coaX coaX AGI25546.1 AGI25546.1 AGI24155.1 AGI24155.1 AGI25046.1 AGI25046.1 AGI22339.1 AGI22339.1 AGI26207.1 AGI26207.1 AGI26802.1 AGI26802.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
birABifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (314 aa)    
Predicted Functional Partners:
AGI26111.1
Pyruvate carboxylase, propionyl-CoA carboxylase; COG0439 Biotin carboxylase.
 
 0.994
AGI22422.1
Sporulation domain-containing protein.
 
    0.962
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.959
coaX
Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
  
    0.959
AGI25546.1
Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone.
 
    0.949
AGI24155.1
COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit.
  
 0.900
AGI25046.1
COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit.
  
 0.898
AGI22339.1
COG0439 Biotin carboxylase.
  
 0.897
AGI26207.1
acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 0.897
AGI26802.1
COG0439 Biotin carboxylase.
 0.893
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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