node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI22154.1 | AGI24007.1 | H681_01360 | H681_10675 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | 0.849 |
AGI22154.1 | AGI26837.1 | H681_01360 | H681_24850 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.965 |
AGI22154.1 | cysG | H681_01360 | H681_13625 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.892 |
AGI22154.1 | hemA | H681_01360 | H681_20640 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.883 |
AGI22154.1 | hemC | H681_01360 | H681_01260 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
AGI22154.1 | hemL | H681_01360 | H681_03425 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.989 |
AGI22569.1 | cysG | H681_03435 | H681_13625 | Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.419 |
AGI22569.1 | hemL | H681_03435 | H681_03425 | Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.682 |
AGI22569.1 | thiE | H681_03435 | H681_03430 | Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
AGI23605.1 | AGI26837.1 | H681_08655 | H681_24850 | COG0527 Aspartokinases; Belongs to the aspartokinase family. | Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.682 |
AGI23605.1 | cysG | H681_08655 | H681_13625 | COG0527 Aspartokinases; Belongs to the aspartokinase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.402 |
AGI23605.1 | hemL | H681_08655 | H681_03425 | COG0527 Aspartokinases; Belongs to the aspartokinase family. | COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.682 |
AGI24007.1 | AGI22154.1 | H681_10675 | H681_01360 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.849 |
AGI24007.1 | cysG | H681_10675 | H681_13625 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.960 |
AGI24007.1 | hemA | H681_10675 | H681_20640 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.784 |
AGI24007.1 | hemC | H681_10675 | H681_01260 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.982 |
AGI24007.1 | hemL | H681_10675 | H681_03425 | uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family. | COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.709 |
AGI24443.1 | AGI26837.1 | H681_12865 | H681_24850 | PpsD; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.685 |
AGI24443.1 | hemL | H681_12865 | H681_03425 | PpsD; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.831 |
AGI26837.1 | AGI22154.1 | H681_24850 | H681_01360 | Aminotransferase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.965 |