node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI22088.1 | AGI25111.1 | H681_01030 | H681_16215 | Hypothetical protein. | COG1376 Uncharacterized protein conserved in bacteria. | 0.480 |
AGI23017.1 | AGI25111.1 | H681_05685 | H681_16215 | Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | COG1376 Uncharacterized protein conserved in bacteria. | 0.411 |
AGI24615.1 | AGI25111.1 | H681_13725 | H681_16215 | COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. | COG1376 Uncharacterized protein conserved in bacteria. | 0.615 |
AGI25109.1 | AGI25111.1 | H681_16205 | H681_16215 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | COG1376 Uncharacterized protein conserved in bacteria. | 0.821 |
AGI25109.1 | AGI25112.1 | H681_16205 | H681_16220 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | COG1309 Transcriptional regulator. | 0.667 |
AGI25109.1 | AGI25114.1 | H681_16205 | H681_16230 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.439 |
AGI25109.1 | lexA | H681_16205 | H681_16225 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.449 |
AGI25109.1 | nagZ | H681_16205 | H681_16210 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.798 |
AGI25111.1 | AGI22088.1 | H681_16215 | H681_01030 | COG1376 Uncharacterized protein conserved in bacteria. | Hypothetical protein. | 0.480 |
AGI25111.1 | AGI23017.1 | H681_16215 | H681_05685 | COG1376 Uncharacterized protein conserved in bacteria. | Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. | 0.411 |
AGI25111.1 | AGI24615.1 | H681_16215 | H681_13725 | COG1376 Uncharacterized protein conserved in bacteria. | COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. | 0.615 |
AGI25111.1 | AGI25109.1 | H681_16215 | H681_16205 | COG1376 Uncharacterized protein conserved in bacteria. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.821 |
AGI25111.1 | AGI25112.1 | H681_16215 | H681_16220 | COG1376 Uncharacterized protein conserved in bacteria. | COG1309 Transcriptional regulator. | 0.677 |
AGI25111.1 | AGI25114.1 | H681_16215 | H681_16230 | COG1376 Uncharacterized protein conserved in bacteria. | Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.444 |
AGI25111.1 | AGI26395.1 | H681_16215 | H681_22640 | COG1376 Uncharacterized protein conserved in bacteria. | Penicillin-binding protein 1A; COG5009 Membrane carboxypeptidase/penicillin-binding protein. | 0.523 |
AGI25111.1 | lexA | H681_16215 | H681_16225 | COG1376 Uncharacterized protein conserved in bacteria. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.455 |
AGI25111.1 | nagZ | H681_16215 | H681_16210 | COG1376 Uncharacterized protein conserved in bacteria. | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.828 |
AGI25112.1 | AGI25109.1 | H681_16220 | H681_16205 | COG1309 Transcriptional regulator. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.667 |
AGI25112.1 | AGI25111.1 | H681_16220 | H681_16215 | COG1309 Transcriptional regulator. | COG1376 Uncharacterized protein conserved in bacteria. | 0.677 |
AGI25112.1 | AGI25114.1 | H681_16220 | H681_16230 | COG1309 Transcriptional regulator. | Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.503 |