node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI25507.1 | argA | H681_18200 | H681_23495 | COG1643 HrpA-like helicases. | N-acetylglutamate synthase; COG0548 Acetylglutamate kinase. | 0.423 |
AGI25507.1 | glnE | H681_18200 | H681_22495 | COG1643 HrpA-like helicases. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.516 |
AGI26363.1 | AGI26364.1 | H681_22480 | H681_22485 | COG0438 Glycosyltransferase. | Lipopolysaccharide heptosyltransferase I; COG0859 ADP-heptose:LPS heptosyltransferase. | 0.993 |
AGI26363.1 | glnE | H681_22480 | H681_22495 | COG0438 Glycosyltransferase. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.485 |
AGI26364.1 | AGI26363.1 | H681_22485 | H681_22480 | Lipopolysaccharide heptosyltransferase I; COG0859 ADP-heptose:LPS heptosyltransferase. | COG0438 Glycosyltransferase. | 0.993 |
AGI26364.1 | glnE | H681_22485 | H681_22495 | Lipopolysaccharide heptosyltransferase I; COG0859 ADP-heptose:LPS heptosyltransferase. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.660 |
AGI26369.1 | aceE-2 | H681_22510 | H681_22500 | Hypothetical protein; COG2203 FOG: GAF domain. | Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.455 |
AGI26369.1 | glnE | H681_22510 | H681_22495 | Hypothetical protein; COG2203 FOG: GAF domain. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.486 |
AGI26369.1 | gltB | H681_22510 | H681_22595 | Hypothetical protein; COG2203 FOG: GAF domain. | COG0067 Glutamate synthase domain 1. | 0.515 |
AGI26460.1 | AGI26670.1 | H681_22965 | H681_24015 | COG0174 Glutamine synthetase. | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.554 |
AGI26460.1 | glnE | H681_22965 | H681_22495 | COG0174 Glutamine synthetase. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.633 |
AGI26460.1 | gltB | H681_22965 | H681_22595 | COG0174 Glutamine synthetase. | COG0067 Glutamate synthase domain 1. | 0.970 |
AGI26670.1 | AGI26460.1 | H681_24015 | H681_22965 | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | COG0174 Glutamine synthetase. | 0.554 |
AGI26670.1 | argA | H681_24015 | H681_23495 | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | N-acetylglutamate synthase; COG0548 Acetylglutamate kinase. | 0.817 |
AGI26670.1 | glnD | H681_24015 | H681_07550 | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.879 |
AGI26670.1 | glnE | H681_24015 | H681_22495 | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.583 |
AGI26670.1 | gltB | H681_24015 | H681_22595 | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | COG0067 Glutamate synthase domain 1. | 0.764 |
aceE-2 | AGI26369.1 | H681_22500 | H681_22510 | Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Hypothetical protein; COG2203 FOG: GAF domain. | 0.455 |
aceE-2 | glnE | H681_22500 | H681_22495 | Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.525 |
argA | AGI25507.1 | H681_23495 | H681_18200 | N-acetylglutamate synthase; COG0548 Acetylglutamate kinase. | COG1643 HrpA-like helicases. | 0.423 |