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glnE glnE glnD glnD AGI26364.1 AGI26364.1 AGI26460.1 AGI26460.1 gltB gltB argA argA AGI26670.1 AGI26670.1 aceE-2 aceE-2 AGI25507.1 AGI25507.1 AGI26369.1 AGI26369.1 AGI26363.1 AGI26363.1
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (981 aa)    
Predicted Functional Partners:
glnD
PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
   
 0.777
AGI26364.1
Lipopolysaccharide heptosyltransferase I; COG0859 ADP-heptose:LPS heptosyltransferase.
      0.660
AGI26460.1
COG0174 Glutamine synthetase.
 
  
 0.633
gltB
COG0067 Glutamate synthase domain 1.
     
 0.602
argA
N-acetylglutamate synthase; COG0548 Acetylglutamate kinase.
 
   
 0.589
AGI26670.1
COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.
 
 
 
 0.583
aceE-2
Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.525
AGI25507.1
COG1643 HrpA-like helicases.
  
     0.516
AGI26369.1
Hypothetical protein; COG2203 FOG: GAF domain.
     
 0.486
AGI26363.1
COG0438 Glycosyltransferase.
       0.485
Your Current Organism:
Pseudomonas sp. ATCC 13867
NCBI taxonomy Id: 1294143
Other names: P. sp. ATCC 13867, Pseudomonas denitrificans ATCC 13867
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