node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI22571.1 | AGI24991.1 | H681_03445 | H681_15615 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.921 |
AGI22571.1 | AGI25839.1 | H681_03445 | H681_19860 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.927 |
AGI22571.1 | AGI26041.1 | H681_03445 | H681_20870 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | 0.458 |
AGI22571.1 | ilvC | H681_03445 | H681_20860 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.615 |
AGI22571.1 | ilvD | H681_03445 | H681_23360 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.983 |
AGI22571.1 | leuA | H681_03445 | H681_18825 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.975 |
AGI22571.1 | leuC | H681_03445 | H681_16720 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.619 |
AGI22571.1 | leuD | H681_03445 | H681_16715 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.477 |
AGI22571.1 | panB | H681_03445 | H681_20975 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.921 |
AGI24991.1 | AGI22571.1 | H681_15615 | H681_03445 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.921 |
AGI24991.1 | AGI25839.1 | H681_15615 | H681_19860 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.909 |
AGI24991.1 | ilvD | H681_15615 | H681_23360 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.916 |
AGI24991.1 | leuA | H681_15615 | H681_18825 | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.908 |
AGI25839.1 | AGI22571.1 | H681_19860 | H681_03445 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.927 |
AGI25839.1 | AGI24991.1 | H681_19860 | H681_15615 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aminotransferase AlaT; COG0436 Aspartate/tyrosine/aromatic aminotransferase. | 0.909 |
AGI25839.1 | ilvD | H681_19860 | H681_23360 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.916 |
AGI25839.1 | leuA | H681_19860 | H681_18825 | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.910 |
AGI26041.1 | AGI22571.1 | H681_20870 | H681_03445 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.458 |
AGI26041.1 | ilvC | H681_20870 | H681_20860 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
AGI26041.1 | ilvD | H681_20870 | H681_23360 | Acetolactate synthase 3 catalytic subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.890 |