node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGI26780.1 | AGI26781.1 | H681_24565 | H681_24570 | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | COG4311 Sarcosine oxidase delta subunit. | 0.998 |
AGI26780.1 | AGI26782.1 | H681_24565 | H681_24575 | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | 0.999 |
AGI26780.1 | gcvP | H681_24565 | H681_01490 | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.912 |
AGI26780.1 | glyA-2 | H681_24565 | H681_24560 | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
AGI26781.1 | AGI26780.1 | H681_24570 | H681_24565 | COG4311 Sarcosine oxidase delta subunit. | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | 0.998 |
AGI26781.1 | AGI26782.1 | H681_24570 | H681_24575 | COG4311 Sarcosine oxidase delta subunit. | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | 0.999 |
AGI26781.1 | gcvP | H681_24570 | H681_01490 | COG4311 Sarcosine oxidase delta subunit. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.906 |
AGI26781.1 | gcvT | H681_24570 | H681_01480 | COG4311 Sarcosine oxidase delta subunit. | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. | 0.686 |
AGI26781.1 | glyA-2 | H681_24570 | H681_24560 | COG4311 Sarcosine oxidase delta subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
AGI26782.1 | AGI26780.1 | H681_24575 | H681_24565 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Sarcosine oxidase subunit beta; COG0665 Glycine/D-amino acid oxidases (deaminating). | 0.999 |
AGI26782.1 | AGI26781.1 | H681_24575 | H681_24570 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | COG4311 Sarcosine oxidase delta subunit. | 0.999 |
AGI26782.1 | folD | H681_24575 | H681_10770 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.687 |
AGI26782.1 | gcvH | H681_24575 | H681_01485 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.937 |
AGI26782.1 | gcvP | H681_24575 | H681_01490 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
AGI26782.1 | glyA-2 | H681_24575 | H681_24560 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
AGI26782.1 | purH | H681_24575 | H681_21725 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.431 |
AGI26782.1 | purL | H681_24575 | H681_18750 | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.520 |
folD | AGI26782.1 | H681_10770 | H681_24575 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Sarcosine oxidase subunit alpha; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | 0.687 |
folD | gcvH | H681_10770 | H681_01485 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.455 |
folD | gcvP | H681_10770 | H681_01490 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.880 |