node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_0096 | MDS_1943 | MDS_0096 | MDS_1943 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Hypothetical protein. | 0.502 |
MDS_0096 | MDS_2560 | MDS_0096 | MDS_2560 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.992 |
MDS_0096 | mtnA | MDS_0096 | MDS_1953 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.489 |
MDS_1943 | MDS_0096 | MDS_1943 | MDS_0096 | Hypothetical protein. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.502 |
MDS_1943 | MDS_2560 | MDS_1943 | MDS_2560 | Hypothetical protein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.704 |
MDS_1943 | MDS_4180 | MDS_1943 | MDS_4180 | Hypothetical protein. | Aldolase/epimerase. | 0.699 |
MDS_1943 | mtnA | MDS_1943 | MDS_1953 | Hypothetical protein. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.854 |
MDS_1956 | MDS_2560 | MDS_1956 | MDS_2560 | Prephenate dehydratase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.605 |
MDS_1956 | MDS_4333 | MDS_1956 | MDS_4333 | Prephenate dehydratase. | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.421 |
MDS_1956 | gyrA | MDS_1956 | MDS_1954 | Prephenate dehydratase. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.757 |
MDS_1956 | ilvA | MDS_1956 | MDS_4553 | Prephenate dehydratase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.512 |
MDS_1956 | mtaD | MDS_1956 | MDS_1952 | Prephenate dehydratase. | N-ethylammeline chlorohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. | 0.507 |
MDS_1956 | mtnA | MDS_1956 | MDS_1953 | Prephenate dehydratase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.634 |
MDS_2560 | MDS_0096 | MDS_2560 | MDS_0096 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.992 |
MDS_2560 | MDS_1943 | MDS_2560 | MDS_1943 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein. | 0.704 |
MDS_2560 | MDS_1956 | MDS_2560 | MDS_1956 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Prephenate dehydratase. | 0.605 |
MDS_2560 | MDS_4180 | MDS_2560 | MDS_4180 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aldolase/epimerase. | 0.557 |
MDS_2560 | ilvA | MDS_2560 | MDS_4553 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.889 |
MDS_2560 | mtnA | MDS_2560 | MDS_1953 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.869 |
MDS_4180 | MDS_1943 | MDS_4180 | MDS_1943 | Aldolase/epimerase. | Hypothetical protein. | 0.699 |