node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_0320 | MDS_1040 | MDS_0320 | MDS_1040 | HAD family hydrolase. | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.927 |
MDS_0320 | MDS_4240 | MDS_0320 | MDS_4240 | HAD family hydrolase. | Riboflavin synthase subunit alpha. | 0.909 |
MDS_0320 | ribD | MDS_0320 | MDS_4241 | HAD family hydrolase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.946 |
MDS_0320 | ribH | MDS_0320 | MDS_4238 | HAD family hydrolase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.910 |
MDS_1040 | MDS_0320 | MDS_1040 | MDS_0320 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | HAD family hydrolase. | 0.927 |
MDS_1040 | MDS_4240 | MDS_1040 | MDS_4240 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | Riboflavin synthase subunit alpha. | 0.940 |
MDS_1040 | metK | MDS_1040 | MDS_0488 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.520 |
MDS_1040 | ribB | MDS_1040 | MDS_4239 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.609 |
MDS_1040 | ribD | MDS_1040 | MDS_4241 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.765 |
MDS_1040 | ribH | MDS_1040 | MDS_4238 | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.880 |
MDS_4240 | MDS_0320 | MDS_4240 | MDS_0320 | Riboflavin synthase subunit alpha. | HAD family hydrolase. | 0.909 |
MDS_4240 | MDS_1040 | MDS_4240 | MDS_1040 | Riboflavin synthase subunit alpha. | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.940 |
MDS_4240 | metK | MDS_4240 | MDS_0488 | Riboflavin synthase subunit alpha. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.419 |
MDS_4240 | nusB | MDS_4240 | MDS_4237 | Riboflavin synthase subunit alpha. | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.498 |
MDS_4240 | ribA | MDS_4240 | MDS_4232 | Riboflavin synthase subunit alpha. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.996 |
MDS_4240 | ribB | MDS_4240 | MDS_4239 | Riboflavin synthase subunit alpha. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
MDS_4240 | ribD | MDS_4240 | MDS_4241 | Riboflavin synthase subunit alpha. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.998 |
MDS_4240 | ribH | MDS_4240 | MDS_4238 | Riboflavin synthase subunit alpha. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.998 |
MDS_4240 | thiL | MDS_4240 | MDS_4236 | Riboflavin synthase subunit alpha. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.501 |
metK | MDS_1040 | MDS_0488 | MDS_1040 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.520 |