node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_1783 | MDS_2241 | MDS_1783 | MDS_2241 | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aminotransferase AlaT. | 0.907 |
MDS_1783 | MDS_3457 | MDS_1783 | MDS_3457 | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 2-isopropylmalate synthase. | 0.909 |
MDS_1783 | ilvD | MDS_1783 | MDS_4537 | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.912 |
MDS_1783 | ilvE | MDS_1783 | MDS_0651 | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.927 |
MDS_1783 | leuA | MDS_1783 | MDS_3757 | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
MDS_2241 | MDS_1783 | MDS_2241 | MDS_1783 | Aminotransferase AlaT. | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.907 |
MDS_2241 | MDS_3457 | MDS_2241 | MDS_3457 | Aminotransferase AlaT. | 2-isopropylmalate synthase. | 0.909 |
MDS_2241 | ilvD | MDS_2241 | MDS_4537 | Aminotransferase AlaT. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.917 |
MDS_2241 | ilvE | MDS_2241 | MDS_0651 | Aminotransferase AlaT. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.916 |
MDS_2241 | leuA | MDS_2241 | MDS_3757 | Aminotransferase AlaT. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
MDS_2818 | MDS_3457 | MDS_2818 | MDS_3457 | Isopropylmalate isomerase large subunit. | 2-isopropylmalate synthase. | 0.984 |
MDS_2818 | ilvC | MDS_2818 | MDS_3867 | Isopropylmalate isomerase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.932 |
MDS_2818 | ilvD | MDS_2818 | MDS_4537 | Isopropylmalate isomerase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.928 |
MDS_2818 | ilvE | MDS_2818 | MDS_0651 | Isopropylmalate isomerase large subunit. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.539 |
MDS_2818 | leuA | MDS_2818 | MDS_3757 | Isopropylmalate isomerase large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.984 |
MDS_2818 | leuB | MDS_2818 | MDS_1997 | Isopropylmalate isomerase large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.997 |
MDS_2818 | leuC | MDS_2818 | MDS_1995 | Isopropylmalate isomerase large subunit. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.903 |
MDS_3457 | MDS_1783 | MDS_3457 | MDS_1783 | 2-isopropylmalate synthase. | Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.909 |
MDS_3457 | MDS_2241 | MDS_3457 | MDS_2241 | 2-isopropylmalate synthase. | Aminotransferase AlaT. | 0.909 |
MDS_3457 | MDS_2818 | MDS_3457 | MDS_2818 | 2-isopropylmalate synthase. | Isopropylmalate isomerase large subunit. | 0.984 |