node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_0862 | MDS_2004 | MDS_0862 | MDS_2004 | Glycine hydroxymethyltransferase. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.630 |
MDS_0862 | MDS_2560 | MDS_0862 | MDS_2560 | Glycine hydroxymethyltransferase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.933 |
MDS_0862 | MDS_3590 | MDS_0862 | MDS_3590 | Glycine hydroxymethyltransferase. | Short chain dehydrogenase. | 0.904 |
MDS_0862 | MDS_4541 | MDS_0862 | MDS_4541 | Glycine hydroxymethyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.914 |
MDS_0862 | fmt | MDS_0862 | MDS_0072 | Glycine hydroxymethyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
MDS_0862 | glyA | MDS_0862 | MDS_0871 | Glycine hydroxymethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.715 |
MDS_0862 | glyA-2 | MDS_0862 | MDS_1373 | Glycine hydroxymethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.717 |
MDS_0862 | purH | MDS_0862 | MDS_0793 | Glycine hydroxymethyltransferase. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.981 |
MDS_0862 | purN | MDS_0862 | MDS_3275 | Glycine hydroxymethyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.950 |
MDS_0862 | thyA | MDS_0862 | MDS_4545 | Glycine hydroxymethyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.920 |
MDS_2004 | MDS_0862 | MDS_2004 | MDS_0862 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase. | 0.630 |
MDS_2004 | MDS_3590 | MDS_2004 | MDS_3590 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Short chain dehydrogenase. | 0.901 |
MDS_2004 | MDS_4541 | MDS_2004 | MDS_4541 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.929 |
MDS_2004 | glyA | MDS_2004 | MDS_0871 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.630 |
MDS_2004 | glyA-2 | MDS_2004 | MDS_1373 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.630 |
MDS_2004 | purH | MDS_2004 | MDS_0793 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.473 |
MDS_2004 | thyA | MDS_2004 | MDS_4545 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.858 |
MDS_2560 | MDS_0862 | MDS_2560 | MDS_0862 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase. | 0.933 |
MDS_2560 | MDS_3590 | MDS_2560 | MDS_3590 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Short chain dehydrogenase. | 0.909 |
MDS_2560 | MDS_4541 | MDS_2560 | MDS_4541 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.927 |