node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_0096 | MDS_2560 | MDS_0096 | MDS_2560 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.992 |
MDS_0096 | MDS_4838 | MDS_0096 | MDS_4838 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Binding-protein-dependent transport systems inner membrane component. | 0.403 |
MDS_0096 | metF | MDS_0096 | MDS_0480 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
MDS_0096 | metK | MDS_0096 | MDS_0488 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.791 |
MDS_0096 | metN | MDS_0096 | MDS_4837 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.613 |
MDS_0096 | metZ | MDS_0096 | MDS_2008 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.862 |
MDS_2560 | MDS_0096 | MDS_2560 | MDS_0096 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.992 |
MDS_2560 | MDS_2720 | MDS_2560 | MDS_2720 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NlpA lipoprotein. | 0.476 |
MDS_2560 | MDS_4839 | MDS_2560 | MDS_4839 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NlpA lipoprotein. | 0.476 |
MDS_2560 | metF | MDS_2560 | MDS_0480 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.994 |
MDS_2560 | metK | MDS_2560 | MDS_0488 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.956 |
MDS_2560 | metN | MDS_2560 | MDS_4837 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.509 |
MDS_2560 | metZ | MDS_2560 | MDS_2008 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.990 |
MDS_2720 | MDS_2560 | MDS_2720 | MDS_2560 | NlpA lipoprotein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.476 |
MDS_2720 | MDS_4838 | MDS_2720 | MDS_4838 | NlpA lipoprotein. | Binding-protein-dependent transport systems inner membrane component. | 0.998 |
MDS_2720 | MDS_4839 | MDS_2720 | MDS_4839 | NlpA lipoprotein. | NlpA lipoprotein. | 0.901 |
MDS_2720 | metF | MDS_2720 | MDS_0480 | NlpA lipoprotein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.422 |
MDS_2720 | metK | MDS_2720 | MDS_0488 | NlpA lipoprotein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.477 |
MDS_2720 | metN | MDS_2720 | MDS_4837 | NlpA lipoprotein. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.997 |
MDS_3351 | metN | MDS_3351 | MDS_4837 | ABC transporter related protein. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.784 |