node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MDS_0634 | MDS_2560 | MDS_0634 | MDS_2560 | O-acetylhomoserine aminocarboxypropyltransferase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.959 |
MDS_0634 | MDS_2720 | MDS_0634 | MDS_2720 | O-acetylhomoserine aminocarboxypropyltransferase. | NlpA lipoprotein. | 0.710 |
MDS_0634 | MDS_4839 | MDS_0634 | MDS_4839 | O-acetylhomoserine aminocarboxypropyltransferase. | NlpA lipoprotein. | 0.710 |
MDS_0634 | cysC | MDS_0634 | MDS_0978 | O-acetylhomoserine aminocarboxypropyltransferase. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.617 |
MDS_0634 | metE | MDS_0634 | MDS_3162 | O-acetylhomoserine aminocarboxypropyltransferase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.940 |
MDS_2560 | MDS_0634 | MDS_2560 | MDS_0634 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine aminocarboxypropyltransferase. | 0.959 |
MDS_2560 | MDS_2720 | MDS_2560 | MDS_2720 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NlpA lipoprotein. | 0.476 |
MDS_2560 | MDS_4839 | MDS_2560 | MDS_4839 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NlpA lipoprotein. | 0.476 |
MDS_2560 | cysC | MDS_2560 | MDS_0978 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.562 |
MDS_2560 | metE | MDS_2560 | MDS_3162 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.988 |
MDS_2560 | metK | MDS_2560 | MDS_0488 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.956 |
MDS_2560 | metN | MDS_2560 | MDS_4837 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.509 |
MDS_2720 | MDS_0634 | MDS_2720 | MDS_0634 | NlpA lipoprotein. | O-acetylhomoserine aminocarboxypropyltransferase. | 0.710 |
MDS_2720 | MDS_2560 | MDS_2720 | MDS_2560 | NlpA lipoprotein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.476 |
MDS_2720 | MDS_4838 | MDS_2720 | MDS_4838 | NlpA lipoprotein. | Binding-protein-dependent transport systems inner membrane component. | 0.998 |
MDS_2720 | MDS_4839 | MDS_2720 | MDS_4839 | NlpA lipoprotein. | NlpA lipoprotein. | 0.901 |
MDS_2720 | cysC | MDS_2720 | MDS_0978 | NlpA lipoprotein. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.551 |
MDS_2720 | metE | MDS_2720 | MDS_3162 | NlpA lipoprotein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.459 |
MDS_2720 | metK | MDS_2720 | MDS_0488 | NlpA lipoprotein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.477 |
MDS_2720 | metN | MDS_2720 | MDS_4837 | NlpA lipoprotein. | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.997 |