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ilvE ilvE ilvD ilvD leuA leuA ilvC ilvC hom hom ilvB ilvB vorB vorB vorA vorA thrB thrB vorC vorC aksA aksA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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ilvEAminotransferase (subgroup III) similar to Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (287 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.999
leuA
2-isopropylmalate synthase; Citation: J. Bac. 176(15): 4590-6 [M. thermoautotrophicum] Porat. I. and Whitman, W.B. Unpublished deletion mutant; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.990
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.948
hom
Homoserine dehydrogenase; Citation: Marchenko GN, Marchenko ND, Tsygankov YD, Chistoserdov AY. (1999)Microbiology 145:3273-82.
 
 
 0.947
ilvB
Acetohydroxyacid synthase large subunit; Citation: Genetics 152:1439.
  
 
 0.946
vorB
2-oxoisovalerate oxidoreductase subunit beta; Citation: Tersteegen, A., et al. 1997. Eur. J. Biochem. 244:862-8.
  
 
 0.916
vorA
2-oxoisovalerate oxidoreductase subunit alpha; Citation: Tersteegen, A., et al. 1997. Eur. J. Biochem. 244:862-8.
    
 0.912
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.909
vorC
2-oxoisovalerate oxidoreductase subunit gamma; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8.
    
  0.903
aksA
2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.897
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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