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cbiX(s) cbiX(s) MMP0089 MMP0089 cbiL cbiL gtrA gtrA cbiG cbiG cbiD cbiD cobA cobA MMP0493 MMP0493 cbiE cbiE cbiC cbiC cbiJ cbiJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cbiX(s)Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (144 aa)    
Predicted Functional Partners:
MMP0089
Conserved hypothetical protein.
  
 
 0.988
cbiL
Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.986
gtrA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.915
cbiG
Cobalamin (vitamin B12) biosynthesis CbiG protein.
 
   
 0.911
cbiD
Cobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
   
 0.910
cobA
uroporphyrin-III C-methyltransferase; Citation: J Bacteriol. 1991 Aug;173(15):4637-45; Belongs to the precorrin methyltransferase family.
  
  
 0.887
MMP0493
Probable metal chelatase.
 
   
 0.874
cbiE
Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
 
   
 0.867
cbiC
Precorrin-8X methylmutase CbiC/CobH.
 
  
 0.854
cbiJ
Precorrin-6x reductase CbiJ/CobK.
     
 0.846
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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