STRINGSTRING
rfcB rfcB pcnA pcnA fen-1 fen-1 dnaB dnaB rpa rpa MMP0122 MMP0122 lig lig priL priL MMP0470 MMP0470 MMP0748 MMP0748 MMP0030 MMP0030
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfcBReplication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (486 aa)    
Predicted Functional Partners:
pcnA
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 0.981
fen-1
Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...]
  
 0.966
dnaB
DNA polymerase family B; Citation: J Bact 176:6402-6403 1994. Genes. Genet. Syst. 1998; 73: 323-336.
  
 0.957
rpa
Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91.
 
 0.947
MMP0122
Conserved hypothetical protein.
  
 0.940
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.926
priL
Putative DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 0.904
MMP0470
MCM family related protein; Citation: Nucleic Acids Res. 1992; 20: 5571-7. Molec. Microbiol. 1998; 29: 955-961; Belongs to the MCM family.
 
 
 0.891
MMP0748
MCM family related protein; Citation: Nucleic Acids Res. 1992; 20: 5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family.
 
 
 0.891
MMP0030
DNA replication protein; Citation: Nucleic Acids Res. 1992; 20:5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family.
 
 
 0.887
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.