node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0337 | MMP0338 | MMP0337 | MMP0338 | Conserved hypothetical protein. | Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. | 0.696 |
MMP0337 | hjc | MMP0337 | MMP0336 | Conserved hypothetical protein. | Archaeal Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.964 |
MMP0338 | MMP0337 | MMP0338 | MMP0337 | Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. | Conserved hypothetical protein. | 0.696 |
MMP0338 | MMP0415 | MMP0338 | MMP0415 | Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | 0.733 |
MMP0338 | hjc | MMP0338 | MMP0336 | Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. | Archaeal Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.679 |
MMP0415 | MMP0338 | MMP0415 | MMP0338 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. | 0.733 |
MMP0415 | RNase | MMP0415 | MMP1374 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.458 |
MMP0415 | dnaG | MMP0415 | MMP1286 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.916 |
MMP0415 | fen-1 | MMP0415 | MMP1313 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.852 |
MMP0415 | hjc | MMP0415 | MMP0336 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Archaeal Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.862 |
MMP0415 | recJ | MMP0415 | MMP1682 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Single stranded DNA-specific exonuclease; Citation: J. Bacteriol. 182 (3), 607-612 (2000). | 0.876 |
MMP0415 | xseA | MMP0415 | MMP0732 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Exonuclease VII, large subunit:OB-fold nucleic acid binding domain. | 0.408 |
RNase | MMP0415 | MMP1374 | MMP0415 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | 0.458 |
RNase | dnaG | MMP1374 | MMP1286 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.763 |
RNase | fen-1 | MMP1374 | MMP1313 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.977 |
RNase | hjc | MMP1374 | MMP0336 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Archaeal Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. | 0.647 |
RNase | radA | MMP1374 | MMP1222 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.901 |
RNase | recJ | MMP1374 | MMP1682 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Single stranded DNA-specific exonuclease; Citation: J. Bacteriol. 182 (3), 607-612 (2000). | 0.781 |
RNase | xseA | MMP1374 | MMP0732 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Exonuclease VII, large subunit:OB-fold nucleic acid binding domain. | 0.477 |
dnaG | MMP0415 | MMP1286 | MMP0415 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | 0.916 |