node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0382 | leuD-2 | MMP0382 | MMP0381 | RNase L inhibitor; Citation: J Bio Chem 270:13308-13317 1995. | 3-isopropylmalate dehydratase small subunit Related; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.934 |
MMP0382 | pyrH | MMP0382 | MMP0385 | RNase L inhibitor; Citation: J Bio Chem 270:13308-13317 1995. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.431 |
aksA | aksF | MMP0153 | MMP0880 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 0.988 |
aksA | ilvC | MMP0153 | MMP0654 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.820 |
aksA | ilvN | MMP0153 | MMP0651 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetohydroxyacid synthase small subunit. | 0.789 |
aksA | leuA | MMP0153 | MMP1063 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Citation: J. Bac. 176(15): 4590-6 [M. thermoautotrophicum] Porat. I. and Whitman, W.B. Unpublished deletion mutant; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.907 |
aksA | leuB | MMP0153 | MMP0539 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Citation: J Bact 182:5013. | 0.780 |
aksA | leuC | MMP0153 | MMP1149 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.744 |
aksA | leuC-2 | MMP0153 | MMP1480 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Aconitase Family; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.973 |
aksA | leuD-2 | MMP0153 | MMP0381 | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit Related; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.970 |
aksF | aksA | MMP0880 | MMP0153 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.988 |
aksF | ilvC | MMP0880 | MMP0654 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.843 |
aksF | ilvN | MMP0880 | MMP0651 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | Acetohydroxyacid synthase small subunit. | 0.837 |
aksF | leuA | MMP0880 | MMP1063 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 2-isopropylmalate synthase; Citation: J. Bac. 176(15): 4590-6 [M. thermoautotrophicum] Porat. I. and Whitman, W.B. Unpublished deletion mutant; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.737 |
aksF | leuC | MMP0880 | MMP1149 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.979 |
aksF | leuC-2 | MMP0880 | MMP1480 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | Aconitase Family; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
aksF | leuD-2 | MMP0880 | MMP0381 | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 3-isopropylmalate dehydratase small subunit Related; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.985 |
ilvC | aksA | MMP0654 | MMP0153 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-oxosuberate synthase, first step; Citation: Biochem. 37:10108; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.820 |
ilvC | aksF | MMP0654 | MMP0880 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-oxosuberate synthase, last step; Citation: J Bact 182:5013; Biochem. 37:10108. | 0.843 |
ilvC | ilvN | MMP0654 | MMP0651 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetohydroxyacid synthase small subunit. | 0.999 |