node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0230 | mptA | MMP0230 | MMP0034 | Conserved hypothetical protein; Metal-dependent phosphohydrolase HD domain. | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.962 |
MMP0230 | mptD | MMP0230 | MMP0243 | Conserved hypothetical protein; Metal-dependent phosphohydrolase HD domain. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.860 |
MMP0230 | mptE | MMP0230 | MMP0579 | Conserved hypothetical protein; Metal-dependent phosphohydrolase HD domain. | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.860 |
MMP0442 | aroK | MMP0442 | MMP0320 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Shikimate kinase (archaeal); Citation: J. Bacteriol. 183:292-300. | 0.531 |
MMP0442 | mptD | MMP0442 | MMP0243 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.484 |
MMP0442 | mptE | MMP0442 | MMP0579 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.628 |
MMP0442 | ribK | MMP0442 | MMP0184 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical archaeal protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.671 |
MMP0581 | act | MMP0581 | MMP0580 | Conserved hypothetical protein. | Radical-activating enzyme. | 0.601 |
MMP0581 | mptE | MMP0581 | MMP0579 | Conserved hypothetical protein. | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.956 |
MMP1580 | mch | MMP1580 | MMP1191 | Dihydropteroate synthase, DHPS:Dihydropteroate synthase-related protein synthase-related protein. | N5,N10-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. | 0.724 |
MMP1580 | mptA | MMP1580 | MMP0034 | Dihydropteroate synthase, DHPS:Dihydropteroate synthase-related protein synthase-related protein. | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.508 |
MMP1580 | mptD | MMP1580 | MMP0243 | Dihydropteroate synthase, DHPS:Dihydropteroate synthase-related protein synthase-related protein. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.420 |
MMP1580 | mptE | MMP1580 | MMP0579 | Dihydropteroate synthase, DHPS:Dihydropteroate synthase-related protein synthase-related protein. | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.620 |
act | MMP0581 | MMP0580 | MMP0581 | Radical-activating enzyme. | Conserved hypothetical protein. | 0.601 |
act | mch | MMP0580 | MMP1191 | Radical-activating enzyme. | N5,N10-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. | 0.503 |
act | mptE | MMP0580 | MMP0579 | Radical-activating enzyme. | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.790 |
aroK | MMP0442 | MMP0320 | MMP0442 | Shikimate kinase (archaeal); Citation: J. Bacteriol. 183:292-300. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.531 |
aroK | mptD | MMP0320 | MMP0243 | Shikimate kinase (archaeal); Citation: J. Bacteriol. 183:292-300. | Conserved hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. | 0.430 |
aroK | mptE | MMP0320 | MMP0579 | Shikimate kinase (archaeal); Citation: J. Bacteriol. 183:292-300. | Conserved hypothetical archaeal protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. | 0.573 |
aroK | ribK | MMP0320 | MMP0184 | Shikimate kinase (archaeal); Citation: J. Bacteriol. 183:292-300. | Conserved hypothetical archaeal protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.405 |