node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0647 | MMP0649 | MMP0647 | MMP0649 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Carbamoyltransferase. | 0.789 |
MMP0647 | MMP1125 | MMP0647 | MMP1125 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Conserved hypothetical protein. | 0.626 |
MMP0647 | MMP1126 | MMP0647 | MMP1126 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.490 |
MMP0647 | ilvB | MMP0647 | MMP0650 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Acetohydroxyacid synthase large subunit; Citation: Genetics 152:1439. | 0.530 |
MMP0647 | ilvN | MMP0647 | MMP0651 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Acetohydroxyacid synthase small subunit. | 0.511 |
MMP0647 | metS | MMP0647 | MMP0326 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.408 |
MMP0647 | prf1 | MMP0647 | MMP1131 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Peptide chain release factor aRF, subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.730 |
MMP0647 | rtcA | MMP0647 | MMP0648 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.984 |
MMP0647 | rtcB | MMP0647 | MMP1392 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Protein of unknown function UPF0027; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family. | 0.967 |
MMP0647 | thiL | MMP0647 | MMP1124 | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | AIR synthase related protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.616 |
MMP0649 | MMP0647 | MMP0649 | MMP0647 | Carbamoyltransferase. | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.789 |
MMP0649 | ilvB | MMP0649 | MMP0650 | Carbamoyltransferase. | Acetohydroxyacid synthase large subunit; Citation: Genetics 152:1439. | 0.533 |
MMP0649 | ilvN | MMP0649 | MMP0651 | Carbamoyltransferase. | Acetohydroxyacid synthase small subunit. | 0.537 |
MMP0649 | rtcA | MMP0649 | MMP0648 | Carbamoyltransferase. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.790 |
MMP1125 | MMP0647 | MMP1125 | MMP0647 | Conserved hypothetical protein. | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.626 |
MMP1125 | MMP1126 | MMP1125 | MMP1126 | Conserved hypothetical protein. | Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.809 |
MMP1125 | rtcA | MMP1125 | MMP0648 | Conserved hypothetical protein. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. | 0.794 |
MMP1125 | thiL | MMP1125 | MMP1124 | Conserved hypothetical protein. | AIR synthase related protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.941 |
MMP1126 | MMP0647 | MMP1126 | MMP0647 | Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | ATP/GTP-binding site motif A (P-loop):Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.490 |
MMP1126 | MMP1125 | MMP1126 | MMP1125 | Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Conserved hypothetical protein. | 0.809 |