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chiB chiB cobQ cobQ cobY/cofC cobY/cofC cbiC cbiC cbiA-2 cbiA-2 cobS cobS cbiD cbiD MMP1663 MMP1663 MMP0493 MMP0493 MMP0950 MMP0950 cbiH cbiH
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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chiBCobalamin biosynthesis protein B; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (306 aa)    
Predicted Functional Partners:
cobQ
Cobyrinic acid a,c-diamide synthase:Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 0.995
cobY/cofC
Nucleoside triphosphate: 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase; Appears to catalyze the guanylation of both (S)-2-phospholactate and adenosylcobinamide phosphate; Citation: M. G. Thomas and J. C. Escalante-Semerena, J. Bacteriol., 2000, 182, 4227; Nat. Prod. Rep., 2002, 19(2), 133 - 147.
  
 
  0.940
cbiC
Precorrin-8X methylmutase CbiC/CobH.
 
  
 0.905
cbiA-2
Cobyrinic acid a,c-diamide synthase:Cobyrinic acid a,c-diamide synthase CbiA.
  
 0.905
cobS
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.887
cbiD
Cobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
  
  
 0.874
MMP1663
Conserved hypothetical protein.
       0.827
MMP0493
Probable metal chelatase.
 
  
 0.820
MMP0950
Conserved hypothetical protein.
  
    0.810
cbiH
precorrin-3B C17-methyltransferase; Citation: J. Bacteriol. 175:3303-3316(1993).
 
  
 0.804
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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