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thiL thiL MMP1639 MMP1639 thiE thiE MMP1125 MMP1125 adkA adkA purM-2 purM-2 rtcA rtcA ribH ribH ribB ribB MMP1126 MMP1126 thiC thiC
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query proteins and first shell of interactors
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textmining
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thiLAIR synthase related protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (315 aa)    
Predicted Functional Partners:
MMP1639
Acyl-CoA dehydrogenase.
 
 
 0.974
thiE
Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 
 0.970
MMP1125
Conserved hypothetical protein.
  
    0.941
adkA
Adenylate kinase; Ferber DM, Haney PJ, Berk H, Lynn D, Konisky J. (1997) Gene 185:239-44; Citation: Rusnak P, Haney P, Konisky J. (1995) J Bacteriol 177:2977-81.
     
  0.900
purM-2
AIR synthase related protein:Phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.858
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
    0.791
ribH
Riboflavin synthase, beta subunit (6,7-dimethyl-8-ribityllumazine synthase); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
 
  
 0.762
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
   
 0.744
MMP1126
Putative proliferating-cell nucleolar antigen; Citation: Cancer Commun. 1989;1(4):243-51, Oncogene (1997) 14: 629-640, Genes to Cells (2002) 7: 911-922; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.726
thiC
Thiamine biosynthesis protein, putative; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.721
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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