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cbiD cbiD cbiG cbiG cbiC cbiC cbiJ cbiJ cbiE cbiE cbiL cbiL cbiH cbiH cbiT cbiT cbiF cbiF cbiO cbiO cbiX(s) cbiX(s)
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cbiDCobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa)    
Predicted Functional Partners:
cbiG
Cobalamin (vitamin B12) biosynthesis CbiG protein.
 
 
 0.999
cbiC
Precorrin-8X methylmutase CbiC/CobH.
  
 0.996
cbiJ
Precorrin-6x reductase CbiJ/CobK.
 
 
 0.995
cbiE
Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase.
  
 0.995
cbiL
Precorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.988
cbiH
precorrin-3B C17-methyltransferase; Citation: J. Bacteriol. 175:3303-3316(1993).
 
  
 0.976
cbiT
SAM (and some other nucleotide) binding motif; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
 
  
 0.961
cbiF
Precorrin-4 C11-methyltransferase; Citation: Eur J Biochem 1998 Jun 1; 254(2):341-6.
 
  
 0.954
cbiO
Cobalt transport protein O; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
 
  
 0.914
cbiX(s)
Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
 
   
 0.910
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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