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mvk mvk hmgA hmgA selB selB MMP1211 MMP1211 MMP1212 MMP1212 fni fni MMP1387 MMP1387 rnz rnz thrB thrB uppS uppS carS carS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (317 aa)    
Predicted Functional Partners:
hmgA
Hydroxymethylglutaryl-coenzyme A reductase:3-hydroxy-3-methylglutaryl Coenzyme A reductase; Citation: Protein Expr Purif. 1999 Dec;17(3):435-42, Mol Biol Evol. 2001 Jul;18(7):1378-88; Belongs to the HMG-CoA reductase family.
 
 0.998
selB
Archaeal translation factor specialized for selenocysteine insertion; Citation: J Bacteriol. 2003 Jan;185(1):107-14.
  
  
 0.972
MMP1211
UPF0219 protein MMP1211; Unnamed protein product; Citation: Mol Microbiol. 2000 Aug;37(4):703-16, Genome Res. 2000 Oct;10(10):1468-84; Belongs to the thiolase-like superfamily. UPF0219 family.
 
  
 0.964
MMP1212
Unnamed protein product.
 
 
 0.906
fni
Isopentenyl-diphosphate delta-isomerase related protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.893
MMP1387
Protein of unknown function DUF52; Belongs to the MEMO1 family.
 
   
 0.873
rnz
Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
  
 0.872
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
      
 0.864
uppS
Undecaprenyl pyrophospahte synthetase related protein (Di-trans-poly-cis-decaprenylcistransferase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
 
  
 0.862
carS
Conserved hypothetical archaeal protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
     
 0.816
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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