node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0122 | MMP1219 | MMP0122 | MMP1219 | Conserved hypothetical protein. | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | 0.722 |
MMP0122 | fen-1 | MMP0122 | MMP1313 | Conserved hypothetical protein. | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.877 |
MMP0122 | mre11 | MMP0122 | MMP1340 | Conserved hypothetical protein. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.949 |
MMP0122 | rad50 | MMP0122 | MMP1341 | Conserved hypothetical protein. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.854 |
MMP0122 | radA | MMP0122 | MMP1222 | Conserved hypothetical protein. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.946 |
MMP0122 | radB | MMP0122 | MMP0617 | Conserved hypothetical protein. | DNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.945 |
MMP0122 | rfcB | MMP0122 | MMP0322 | Conserved hypothetical protein. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.940 |
MMP1219 | MMP0122 | MMP1219 | MMP0122 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | Conserved hypothetical protein. | 0.722 |
MMP1219 | fen-1 | MMP1219 | MMP1313 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.972 |
MMP1219 | mre11 | MMP1219 | MMP1340 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.956 |
MMP1219 | rad50 | MMP1219 | MMP1341 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.759 |
MMP1219 | radA | MMP1219 | MMP1222 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.811 |
MMP1219 | radB | MMP1219 | MMP0617 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | DNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.750 |
MMP1219 | rfcB | MMP1219 | MMP0322 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.766 |
MMP1219 | rpa | MMP1219 | MMP1032 | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91. | 0.771 |
MMP1342 | mre11 | MMP1342 | MMP1340 | Conserved hypothetical protein. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.906 |
MMP1342 | rad50 | MMP1342 | MMP1341 | Conserved hypothetical protein. | DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.899 |
fen-1 | MMP0122 | MMP1313 | MMP0122 | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | Conserved hypothetical protein. | 0.877 |
fen-1 | MMP1219 | MMP1313 | MMP1219 | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | Putative dinG ATP-dependent helicase; Citation: J Biol Chem. 2003 279: 29294-28293. | 0.972 |
fen-1 | mre11 | MMP1313 | MMP1340 | Flap endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.989 |