node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP1083 | apt | MMP1083 | MMP0660 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.850 |
MMP1083 | hisF | MMP1083 | MMP1722 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.907 |
MMP1083 | hisH | MMP1083 | MMP0256 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
MMP1083 | hisH2 | MMP1083 | MMP1082 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Similar to bacterial imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
MMP1083 | hpt | MMP1083 | MMP0145 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Hypoxanthine (guanine) phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.850 |
MMP1083 | purB | MMP1083 | MMP0971 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.835 |
MMP1083 | purP | MMP1083 | MMP1373 | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | Conserved hypothetical archaeal protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.806 |
apt | MMP1083 | MMP0660 | MMP1083 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | 0.850 |
apt | hisF | MMP0660 | MMP1722 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.844 |
apt | hisH | MMP0660 | MMP0256 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.813 |
apt | hisH2 | MMP0660 | MMP1082 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Similar to bacterial imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.813 |
apt | hpt | MMP0660 | MMP0145 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine (guanine) phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.907 |
apt | purB | MMP0660 | MMP0971 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.973 |
apt | purC | MMP0660 | MMP0540 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Citation: Tiedeman AA, DeMarini DJ, Parker J, Smith JM. (1990) J Bacteriol 172:6035-41; Belongs to the SAICAR synthetase family. | 0.482 |
apt | purL | MMP0660 | MMP0179 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.522 |
apt | purP | MMP0660 | MMP1373 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Conserved hypothetical archaeal protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.903 |
hisF | MMP1083 | MMP1722 | MMP1083 | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Similar to bacterial imidazoleglycerol-phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family. | 0.907 |
hisF | apt | MMP1722 | MMP0660 | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.844 |
hisF | hisH | MMP1722 | MMP0256 | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
hisF | hisH2 | MMP1722 | MMP1082 | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Similar to bacterial imidazoleglycerol-phosphate synthase, amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |