node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0418 | guaA-2 | MMP0418 | MMP1445 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.929 |
MMP0418 | guaB | MMP0418 | MMP0133 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
MMP0418 | purA | MMP0418 | MMP1432 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.992 |
MMP0418 | purB | MMP0418 | MMP0971 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.780 |
MMP0418 | pyrB | MMP0418 | MMP1659 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Aspartate carbamoyltransferase; Citation: J. Biol Chem 2000 May 26; 275 (21) 15820-7. | 0.447 |
MMP0418 | surE | MMP0418 | MMP1051 | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
argG | asnB | MMP0073 | MMP0918 | Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | 0.930 |
argG | guaB | MMP0073 | MMP0133 | Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.406 |
argG | purA | MMP0073 | MMP1432 | Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.958 |
argG | pyrB | MMP0073 | MMP1659 | Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Aspartate carbamoyltransferase; Citation: J. Biol Chem 2000 May 26; 275 (21) 15820-7. | 0.920 |
asnB | argG | MMP0918 | MMP0073 | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | Argininosuccinate synthase; Citation: Hennigan AN, Reeve JN. (1994). Mol Microbiol 11:655-70; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.930 |
asnB | purA | MMP0918 | MMP1432 | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.962 |
asnB | purB | MMP0918 | MMP0971 | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.658 |
asnB | purL | MMP0918 | MMP0179 | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.731 |
asnB | pyrB | MMP0918 | MMP1659 | Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57. | Aspartate carbamoyltransferase; Citation: J. Biol Chem 2000 May 26; 275 (21) 15820-7. | 0.937 |
guaA-2 | MMP0418 | MMP1445 | MMP0418 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Carbohydrate kinase, PfkB; Belongs to the carbohydrate kinase PfkB family. | 0.929 |
guaA-2 | guaB | MMP1445 | MMP0133 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.994 |
guaA-2 | purA | MMP1445 | MMP1432 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.956 |
guaA-2 | purB | MMP1445 | MMP0971 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.868 |
guaA-2 | purL | MMP1445 | MMP0179 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.785 |