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speH speH speE speE pdaD pdaD mat mat MMP0011 MMP0011 MMP1585 MMP1585 MMP1657 MMP1657 lysA lysA aIF-2B aIF-2B fucA fucA secD secD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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speHS-adenosylmethionine decarboxylase related; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (122 aa)    
Predicted Functional Partners:
speE
SAM (and some other nucleotide) binding motif:Spermine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
 0.999
pdaD
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC, alpha and beta subunits; Citation: Graham et al, J. Biol. Chem. 277:23500-23507(2002); Belongs to the PdaD family.
  
  
 0.989
mat
Archaeal S-adenosylmethionine synthetase (MAT); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
   
 
 0.923
MMP0011
C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
MMP1585
Arginase; Belongs to the arginase family.
     
 0.856
MMP1657
Conserved hypothetical protein.
     0.833
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
  
  
 0.675
aIF-2B
Archaeal transcription initiation factor 2B subunit I; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
     
 0.590
fucA
Class II aldolase/adducin, N-terminal; Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.
     
 0.567
secD
SecD/SecF/SecDF export membrane protein; Involved in protein export.
  
    0.503
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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