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crgA crgA pbpA pbpA wag31 wag31 ftsZ ftsZ cwsA cwsA pbpB pbpB ftsQ ftsQ ABK69759.1 ABK69759.1 whiA whiA ABK71385.1 ABK71385.1 fhaB fhaB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
crgAPutative membrane protein; Involved in cell division; Belongs to the CrgA family. (94 aa)    
Predicted Functional Partners:
pbpA
Penicillin binding protein transpeptidase domain protein; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation.
  
 
 0.967
wag31
DivIVA protein; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. Belongs to the DivIVA family.
  
  
 0.964
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.963
cwsA
Conserved hypothetical protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family.
   
 
 0.945
pbpB
Penicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF03717; Belongs to the transpeptidase family.
 
 
 0.941
ftsQ
Putative Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
   
 
 0.916
ABK69759.1
Anthranilate synthase component 2; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
    0.777
whiA
Conserved hypothetical protein; Involved in cell division and chromosome segregation.
   
  
 0.771
ABK71385.1
Conserved hypothetical protein; Identified by match to protein family HMM PF05949.
  
    0.760
fhaB
FHA domain protein; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress.
  
  
 0.749
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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