node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK74495.1 | PE35 | MSMEG_0061 | MSMEG_0063 | Identified by match to protein family HMM PF01580. | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | 0.727 |
ABK74495.1 | eccA1 | MSMEG_0061 | MSMEG_0059 | Identified by match to protein family HMM PF01580. | ATPase, AAA family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity). | 0.919 |
ABK74495.1 | eccB1 | MSMEG_0061 | MSMEG_0060 | Identified by match to protein family HMM PF01580. | Conserved hypothetical protein; An ATPase (shown for residues 72-479). Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains ; Belongs to the EccB family. | 0.980 |
ABK74495.1 | eccCb1 | MSMEG_0061 | MSMEG_0062 | Identified by match to protein family HMM PF01580. | Ftsk/spoiiie family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. | 0.990 |
ABK74495.1 | eccE1 | MSMEG_0061 | MSMEG_0082 | Identified by match to protein family HMM PF01580. | Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in at least a donor strain. | 0.875 |
ABK74495.1 | espE | MSMEG_0061 | MSMEG_0055 | Identified by match to protein family HMM PF01580. | Hypothetical protein; Identified by Glimmer2; putative. | 0.846 |
ABK74495.1 | espG1 | MSMEG_0061 | MSMEG_0057 | Identified by match to protein family HMM PF01580. | Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Specific chaperone for cognate PE/PPE proteins, plays an important role in preventing aggregation of PE/PPE dimers (By similarity). Also plays a role in DNA conjugation, in at least recipient strain (By similarity). ECO:0000250|UniProtKB:L8FPI5, ; Belongs to the EspG family. | 0.886 |
ABK74495.1 | esxA | MSMEG_0061 | MSMEG_0066 | Identified by match to protein family HMM PF01580. | Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart. | 0.691 |
ABK74495.1 | esxB | MSMEG_0061 | MSMEG_0065 | Identified by match to protein family HMM PF01580. | Conserved hypothetical protein; An exported protein. Plays a role in DNA conjugation, in at least a donor strain ; Belongs to the WXG100 family. CFP-10 subfamily. | 0.729 |
ABK74495.1 | mycP1 | MSMEG_0061 | MSMEG_0083 | Identified by match to protein family HMM PF01580. | Membrane-anchored mycosin mycp1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Belongs to the peptidase S8 family. | 0.823 |
PE35 | ABK74495.1 | MSMEG_0063 | MSMEG_0061 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Identified by match to protein family HMM PF01580. | 0.727 |
PE35 | eccA1 | MSMEG_0063 | MSMEG_0059 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | ATPase, AAA family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity). | 0.743 |
PE35 | eccB1 | MSMEG_0063 | MSMEG_0060 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Conserved hypothetical protein; An ATPase (shown for residues 72-479). Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains ; Belongs to the EccB family. | 0.535 |
PE35 | eccCb1 | MSMEG_0063 | MSMEG_0062 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Ftsk/spoiiie family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. | 0.852 |
PE35 | espE | MSMEG_0063 | MSMEG_0055 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Hypothetical protein; Identified by Glimmer2; putative. | 0.891 |
PE35 | espG1 | MSMEG_0063 | MSMEG_0057 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Specific chaperone for cognate PE/PPE proteins, plays an important role in preventing aggregation of PE/PPE dimers (By similarity). Also plays a role in DNA conjugation, in at least recipient strain (By similarity). ECO:0000250|UniProtKB:L8FPI5, ; Belongs to the EspG family. | 0.805 |
PE35 | esxA | MSMEG_0063 | MSMEG_0066 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart. | 0.760 |
PE35 | esxB | MSMEG_0063 | MSMEG_0065 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Conserved hypothetical protein; An exported protein. Plays a role in DNA conjugation, in at least a donor strain ; Belongs to the WXG100 family. CFP-10 subfamily. | 0.835 |
PE35 | mycP1 | MSMEG_0063 | MSMEG_0083 | PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. | Membrane-anchored mycosin mycp1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Belongs to the peptidase S8 family. | 0.690 |
eccA1 | ABK74495.1 | MSMEG_0059 | MSMEG_0061 | ATPase, AAA family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Plays a role in DNA conjugation, in both donor and recipient strains. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity). | Identified by match to protein family HMM PF01580. | 0.919 |