STRINGSTRING
ABK75430.1 ABK75430.1 ABK70153.1 ABK70153.1 thyA thyA ABK72003.1 ABK72003.1 ABK72783.1 ABK72783.1 thyX thyX ABK76148.1 ABK76148.1 ABK71023.1 ABK71023.1 ABK70439.1 ABK70439.1 ABK69712.1 ABK69712.1 sdaA sdaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK75430.1Dihydrofolate reductase. (175 aa)    
Predicted Functional Partners:
ABK70153.1
Transcriptional regulator, AraC family protein.
 
  
 0.978
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.943
ABK72003.1
Acyltransferase domain protein; Identified by match to protein family HMM PF01553.
  
  
 0.880
ABK72783.1
Arylamine N-acetyltransferase; Identified by match to protein family HMM PF00797.
  
  
 0.752
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.750
ABK76148.1
Adenine deaminase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969.
  
  
 0.736
ABK71023.1
Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family.
  
  
 0.632
ABK70439.1
Cytosine deaminase; Identified by match to protein family HMM PF00383.
  
  
 0.627
ABK69712.1
1-aminocyclopropane-1-carboxylate deaminase; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01274.
      
 0.612
sdaA
L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family.
     
 0.606
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.