node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70019.1 | ABK75025.1 | MSMEG_1578 | MSMEG_0424 | Peptidase M22, glycoprotease; Identified by match to protein family HMM PF00814. | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.642 |
ABK70019.1 | groS | MSMEG_1578 | MSMEG_1582 | Peptidase M22, glycoprotease; Identified by match to protein family HMM PF00814. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.703 |
ABK70160.1 | ABK75025.1 | MSMEG_2792 | MSMEG_0424 | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.643 |
ABK70160.1 | dnaJ-2 | MSMEG_2792 | MSMEG_4504 | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.724 |
ABK70160.1 | dnaK | MSMEG_2792 | MSMEG_0709 | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.695 |
ABK70160.1 | groS | MSMEG_2792 | MSMEG_1582 | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.680 |
ABK70160.1 | grpE | MSMEG_2792 | MSMEG_0710 | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.812 |
ABK70295.1 | ABK75025.1 | MSMEG_5174 | MSMEG_0424 | Regulatory protein GntR, HTH; Identified by match to protein family HMM PF00392. | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.697 |
ABK72999.1 | ABK75025.1 | MSMEG_3761 | MSMEG_0424 | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.642 |
ABK72999.1 | dnaJ-2 | MSMEG_3761 | MSMEG_4504 | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.724 |
ABK72999.1 | dnaK | MSMEG_3761 | MSMEG_0709 | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.697 |
ABK72999.1 | groS | MSMEG_3761 | MSMEG_1582 | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.685 |
ABK72999.1 | grpE | MSMEG_3761 | MSMEG_0710 | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.813 |
ABK75025.1 | ABK70019.1 | MSMEG_0424 | MSMEG_1578 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Peptidase M22, glycoprotease; Identified by match to protein family HMM PF00814. | 0.642 |
ABK75025.1 | ABK70160.1 | MSMEG_0424 | MSMEG_2792 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Clp amino terminal domain protein; Identified by match to protein family HMM PF02861. | 0.643 |
ABK75025.1 | ABK70295.1 | MSMEG_0424 | MSMEG_5174 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Regulatory protein GntR, HTH; Identified by match to protein family HMM PF00392. | 0.697 |
ABK75025.1 | ABK72999.1 | MSMEG_0424 | MSMEG_3761 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Putative Clp protease subunit; Identified by match to protein family HMM PF02861. | 0.642 |
ABK75025.1 | clpB | MSMEG_0424 | MSMEG_0732 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.746 |
ABK75025.1 | clpC1 | MSMEG_0424 | MSMEG_6091 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily. | 0.650 |
ABK75025.1 | dnaJ-2 | MSMEG_0424 | MSMEG_4504 | Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.631 |